Xanax, Percocet, Adderall. It will be a very massive high that is very short. And that person, they're betting if they survive, will come back again and again and again to buy more. Bill Whitaker and Anne Milgram Bill Whitaker and DEA Administrator Anne Milgram 60 Minutes Three years ago, Anne Milgram – a former attorney general of New Jersey – took over the Drug Enforcement Administration. Since then fentanyl has claimed more than 200,000 American lives, although deaths appear to be leveling off. Anne Milgram: Fentanyl is impacting every part of the United States. It's impacting our communities. It's impacting our kids. It's impacting our economy. One of the things that I've learned over the last few years that really stays with me is every single week we lose 22 teens between the ages of 14 and 18. Bill Whitaker: Every week. Anne Milgram: Every single week we're basically losing a high school class somewhere in America. She started putting pictures of people who died from fentanyl in the lobby of DEA headquarters, a daily reminder of the drug's catastrophic impact. Anne Milgram: We're losing a generation. Bill Whitaker: That's what this says. Anne Milgram: Yes. You can see it so clearly when you look, and you see Americans from all walks of life, all states, all communities, young and old, every background possible. We have folks in military uniforms, we've got babies. Bill Whitaker: Oh my God! Bill Whitaker: Someone who just picks up the pill that a parent dropped. Anne Milgram: Yes. The DEA is part of the Department of Justice and conducts intelligence gathering and counter-drug operations worldwide. Milgram oversees 10,000 employees. Anne Milgram: As complex and as massive a problem as this is, it's also not a whodunit. We know who's responsible. It's the Sinaloa Cartel and the Jalisco Cartel that are based in Mexico. They dominate and control the entire global fentanyl supply chain, starting in China, going to Mexico, coming into the United States. Milgram told us this crisis began 10 years ago… when the cartels started to wrestle control of the supply chain from China and began making fentanyl in clandestine labs in Mexico. Bill Whitaker: So these two drug cartels from our neighbor, from Mexico, are responsible for almost 70,000 American deaths a year? Anne Milgram: Yes. Bill Whitaker: How do you fight that? Anne Milgram: We've taken action over the last three years against every single part of that global supply chain, charging Chinese nationals with selling fentanyl precursors, charging and indicting, investigating, members of these cartels at every level and then finally taking hundreds of millions of deadly doses of fentanyl off American streets. And we are making progress but there's so much more that needs to be done. Troy Miller: The majority the fentanyl that we're seeing, about 90%-plus is coming in passenger vehicles. Bill Whitaker and Troy Miller, a 30-year veteran of U.S. Customs and Border Protectio. Bill Whitaker and Troy Miller, a 30-year veteran of U.S. Customs and Border Protectio. 60 Minutes Commissioner Troy Miller, a 30-year veteran of U.S. Customs and Border Protection, told us almost all the fentanyl coming into the country is smuggled through legal ports of entry like here at San Ysidro, between San Diego and Tijuana. It's the busiest land port in the Western Hemisphere. Bill Whitaker: What percentage of the smuggled fentanyl do you think you are catching?